呼吸器内科305研究室では、呼吸器疾患を分子生物学の言葉で記述するべく、様々な手法を用いて、主に肺癌の研究を行っています。
| 氏 名 | 職 名 | |
|---|---|---|
| 鹿毛 秀宣 | Kage Hidenori | 呼吸器内科 教授 |
| 川上 正敬 | Kawakami Masanori | 呼吸器内科 講師 |
| 渡邊 広祐 | Watanabe Kousuke | 次世代プレシジョンメディシン開発講座 特任准教授 |
| 春原 光宏 | Sunohara Mitsuhiro | 保健・健康推進本部 講師 |
| 安藤 孝浩 | Ando Takahiro | 呼吸器内科 助教 |
| 生島 弘彬 | Ikushima Hiroaki | 呼吸器内科 助教 |
| 成田 翔子 | Narita Shoko | 動物資源学 助教 |
| 松本 容子 | Matsumoto Yoko | 保健・健康推進本部 助教 |
| 飯田 崇博 | Iida Takahiro | 医学系研究科 博士課程 |
| 徳永 将勝 | Tokunaga Masakatsu | 医学系研究科 博士課程 |
| 中川 夏樹 | Nakagawa Natsuki | 医学系研究科 博士課程 |
| 杉浦 有理子 | Sugiura Yuriko | 医学系研究科 博士課程 |
| 植木 理子 | Ueki Michiko | 医学系研究科 博士課程 |
| 藤井 洸希 | Fujii Koki | 医学系研究科 博士課程 |
| 何 美玲 | Ka Mirei | 医学系研究科 博士課程 |
| 伊藤 佑 | Ito Yu | 医学系研究科 博士課程 |
| 岩﨑 美香 | Iwasaki Mika | 医学系研究科 博士課程 |
| 戸田 嶺路 | Toda Minemichi | 医学系研究科 博士課程 |
| 本村 英明 | Motomura Hideaki | 医学系研究科 博士課程 |
| Wei Rebekah | 短期研究生 | |
| 楊 正隆 | You Masataka | 医学系研究科 修士課程 |
--- 2023年 ---
Kage H, Shinozaki-Ushiku A, Ishigaki K, Sato Y, Tanabe M, Tanaka S, Tanikawa M, Watanabe K, Kato S, Akagi K, Uchino K, Mitani K, Takahashi S, Miura Y, Ikeda S, Kojima Y, Watanabe K, Mochizuki H, Yamaguchi H, Kawazoe Y, Kashiwabara K, Kohsaka S, Tatsuno K, Ushiku T, Ohe K, Yatomi Y, Seto Y, Aburatani H, Mano H, Miyagawa K, Oda K.
Clinical utility of Todai OncoPanel in the setting of approved comprehensive cancer genomic profiling tests in Japan.
Cancer Sci (Online ahead of print).
PMID: 36601953
Mizuno S, Ikegami M, Koyama T, Sunami K, Ogata D, Kage H, Yanagaki M, Ikeuchi H, Ueno T, Tanikawa M, Oda K, Osuga Y, Mano H, Kohsaka S.
High-Throughput Functional Evaluation of MAP2K1 Variants in Cancer.
Mol Cancer Ther 2023;22:227-239
PMID: 36442478
Matsumoto Y, Kage H, Morota M, Zokumasu K, Ando T, Maemura K, Watanabe K, Kawakami M, Hinata M, Ushiku T, Nakajima J, Nagase T.
Integrin alpha 2 is associated with tumor progression and postoperative recurrence in non-small cell lung cancer.
Cancer Sci. 2020 Jan;111(1):200-208.
PMID: 36151049
Kimura Y, Jo T, Inoue N, Suzukawa M, Tanaka G, Kage H, Kumazawa R, Matsui H, Fushimi K, Yasunaga H, Matsui H.
Association Between Systemic Corticosteroid Use and Mortality in Patients with Epiglottitis.
Laryngoscope 2023;133:344-349.
PMID: 35305022
--- 2022年 ---
Naito Y, Sunami K, Kage H, Komine K, Amano T, Imai M, Koyama T, Ennishi D, Kanai M, Kenmotsu H, Maeda T, Morita S, Sakai D, Watanabe K, Shirota H, Kinoshita I, Yoshioka M, Mamesaya N, Ito M, Kohsaka S, Saigusa Y, Yamamoto K, Hirata M, Tsuchihara K, Yoshino T.
Concordance Between Recommendations from Multidisciplinary Molecular Tumor Boards and Central Consensus for Cancer Treatment in Japan.
JAMA Netw Open 2022;5:e2245081.
PMID: 36469316
Hirokazu Urushiyama, Taisuke Jo, Wakae Hasegawa, Akira Yokoyama, Takahiro Ando, Yukiyo Sakamoto, Ryosuke Kumazawa,
Kazuaki Uda, Nobuaki Michihata, Nobuyasu Awano, Matsui Hiroki, Kiyohide Fushimi, Hideo Yasunaga, Takahide Nagase.
Effect of nintedanib on acute exacerbations of fibrosing interstitial lung diseases: a national database study in Japan.
ERJ Open Res. 2022 Nov 28;8(4):00209-2022.
PMID: 36451844
Nakagawa N, Kawakami M.
Choosing the optimal immunotherapeutic strategies for non-small cell lung cancer based on clinical factors.
Front Oncol. 2022 Aug 12;12:952393.
PMID: 36033471
Sunami K, Naito Y, Komine K, Amano T, Ennishi D, Imai M, Kage H, Kanai M, Kenmotsu H, Koyama T, Maeda T, Morita S, Sakai D, Kohsaka S, Tsuchihara K, Saigusa Y, Yoshino T.
Chronological improvement in precision oncology implementation in Japan.
Cancer Sci 2022;113:3995-4000.
PMID: 35976133
Imai M, Nakamura Y, Sunami K, Kage H, Komine K, Koyama T, Amano T, Ennishi D, Kanai M, Kenmotsu H, Maeda T, Morita S, Sakai D, Bando H, Makiyama A, Suzuki T, Hirata M, Kohsaka S, Tsuchihara K, Naito Y, Yoshino T.
Expert panel consensus recommendations on the use of circulating tumor DNA assays for patients with advanced solid tumors.
Cancer Sci 2022;113:3646-3656.
PMID: 35876224
Roszik J, Lee JJ, Wu YH, Liu X, Kawakami M, Kurie JM, Belouali A, Boca SM, Gupta S, Beckman RA, Madhavan S, Dmitrovsky E.
Real-World Studies Link Nonsteroidal Anti-inflammatory Drug Use to Improved Overall Lung Cancer Survival.
Cancer Res Commun. 2022 Jul;2(7):590-601.
PMID: 35832288
Amano Y, Kage H, Tanaka G, Sato Y, Tanaka M, Nagase T.
Multiple Brain Metastases in a Patient with ROS1 Fusion-Positive Lung Adenocarcinoma as a Disease Flare due to Crizotinib Cessation Caused by Disseminated Aseptic Inflammation from Crizotinib-Associated Renal Cysts: A Case Report.
Case Rep Oncol 2022;15:338-344.
PMID: 35529295
Kage H, Kohsaka S, Tatsuno K, Ueno T, Ikegami M, Zokumasu K, Shinozaki-Ushiku A, Nagai S, Aburatani H, Mano H, Oda K.
Tumor mutational burden measurement using comprehensive genomic profiling assay.
Jpn J Clin Oncol 2022;52:925-929.
PMID: 35482395
Chen Z, Zheng L, Chen Y, Liu X, Kawakami M, Mustachio LM, Roszik J, Ferry-Galow KV, Parchment RE, Liu X, Andresson T, Duncan G, Kurie JM, Rodriguez-Canales J, Liu X, Dmitrovsky E.
Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis.
Cancer Biol Ther. 2022 Dec 31;23(1):265-280.
PMID: 35387560
Tanosaki T, Mikami Y, Shindou H, Suzuki T, Hashidate-Yoshida T, Hosoki K, Kagawa S, Miyata J, Kabata H, Masaki K, Hamamoto R, Kage H, Miyashita N, Makita K, Matsuzaki H, Suzuki Y, Mitani A, Nagase T, Shimizu T, Fukunaga K.
Lysophosphatidylcholine Acyltransferase 1 Deficiency Promotes Pulmonary Emphysema via Apoptosis of Alveolar Epithelial Cells.
Inflammation 2022;45:1765-1779
PMID: 35338433
Miyamoto S, Yamazaki T, Shimizu K, Matsubara T, Kage H, Watanabe K, Kobo H, Matsuyama Y, Rodin G, Yoshiuchi K.
Brief, manualised and semistructured individual psychotherapy programme for patients with advanced cancer in Japan: study protocol for Managing Cancer and Living Meaningfully (CALM) phase 2 trial.
BMJ Open 2022;12(3):e056136
PMID: 35277407
Takahiro Ando, Hidenori Kage, Aya Shinozaki-Ushiku, Kenji Tatsuno, Shuichi Tsutsumi, Kazuhiro Nagayama, Jun Nakajima , Shinji Kohsaka, Kiyoshi Miyagawa, Hiroyuki Aburatani, Hiroyuki Mano, Takahide Nagase.
Composite Clonal Analysis Reveals Transition of NSCLC Subtypes Through Accumulation of Gene Mutations: A Case Report
JTO Clin Res Rep. 2022 Jan 10;3(2):100277.
PMID: 35199052
Takeshi Kawasaki, Natsuki Nakagawa, Maki Murata, Shunsuke Yasuo, Takuo Yoshida, Koichi Ando, Satoshi Okamori, Yohei Okada.
Diagnostic accuracy of urinary antigen tests for legionellosis: A systematic review and meta-analysis.
Respir Investig. 2022 Mar;60(2):205-214.
PMID: 34972680
Maki Murata, Natsuki Nakagawa, Takeshi Kawasaki, Shunsuke Yasuo, Takuo Yoshida, Koichi Ando, Satoshi Okamori, Yohei Okada.
Adverse events during intrahospital transport of critically ill patients: A systematic review and meta-analysis.
Am J Emerg Med. 2022 Feb;52:13-19.
PMID: 34861515
--- 2021年 ---
Noda-Narita S, Kawachi A, Okuyama A, Sadachi R, Hirakawa A, Goto Y, Fujiwara Y, Higashi T, Yonemori K.
First-line treatment for lung cancer among Japanese older patients: A real-world analysis of hospital-based cancer registry data.
PLoS One. 2021; 16(9): e0257489
PMID: 34543332
Ikushima H, Hiraishi Y, Toriumi K, Ando T, Tamiya H, Ishida J, Amano Y, Kage H, Tanaka G, Nagase T.
Multiple cerebral infarctions in ROS1-rearranged lung adenocarcinoma.
Respirol Case Rep 2021;9:e0831.
PMID: 34471540
Kurokawa R, Inui S, Gonoi W, Nakai Y, Ishida M, Watanabe Y, Kubo T, Amano Y, Okamoto K, Kage H, Harada S, Tanaka G, Kawahara T, Nagase T, Moriya K, Abe O.
Standardized reporting systems of chest computed tomography in a population with low coronavirus disease 2019 prevalence: A retrospective comparative study.
Heliyon 2021;7:e07743.
PMID: 34395930
Ando T, Kage H, Matsumoto Y, Zokumasu K, Nagase T.
Lower dose of ethambutol may reduce ocular toxicity without radiological deterioration for Mycobacterium avium complex pulmonary disease.
Respir Investig. 2021 Nov;59(6):777-782.
PMID: 34389250
Mitani A, Hamada K, Yoshikawa N, Morita Y, Horie T, Inoue Y, Saito M, Ishii T, Sunohara M, Takahashi R, Emoto N, Nishimoto N, Murano Y, Okazaki S, Tateishi S, Yao A, Shimura T, Kurano M, Yatomi Y, Yanagimoto S.
Epidemiological study using IgM and IgG antibody titers against SARS-CoV-2 in The University of Tokyo, Japan (UT-CATS).
J Infect Chemother. 27: 1342-1349; 2021.
PMID: 34158239
Manaka K, Sato J, Takeuchi M, Watanabe K, Kage H, Kawai T, Sato Y, Miyagawa T, Yamada D, Kume H, Sato S, Nagase T, Iiri T, Nangaku M, Makita N.
Immune checkpoint inhibitor combination therapies very frequently induce secondary adrenal insufficiency.
Sci Rep 2021;11:11617.
PMID: 34078988
Noda-Narita S, Kanzaki M, Uesaka Y, Suwabe T, Kinowaki K, Marui Y, Hoshino J, Sawa N, Ubara Y.
Paraneoplastic Polymyositis Due to Renal Cell Carcinoma in a Patient with Autosomal Dominant Polycystic Kidney Disease.
Intern Med. 2021; 60(22):3577-3580
PMID: 34053989
Urushiyama H, Jo T, Hasegawa W, Ando T, Sakamoto Y, Uda K, Matsui H, Fushimi K, Yasunaga H, Nagase T.
Preoperative use of pirfenidone and reduced risk of postoperative severe respiratory complications in patients with idiopathic pulmonary fibrosis: Propensity score-matched analysis using a nationwide database in Japan.
Respirology. 26: 590-596; 2021.
PMID: 33870611
Amano Y, Kage H, Tanaka G, Gonoi W, Nakai Y, Kurokawa R, Inui S, Okamoto K, Harada S, Iwabu M, Morizaki Y, Abe O, Moriya K, Nagase T.
Diagnostic prediction of COVID-19 based on clinical and radiological findings in a relatively low COVID-19 prevalence area.
Respir Investig 2021;59:446-453.
PMID: 33865743
Sunami K, Naito Y, Aimono E, Amano T, Ennishi D, Kage H, Kanai M, Komine K, Koyama T, Maeda T, Morita S, Sakai D, Kohsaka S, Tsuchihara K, Yoshino T.
The initial assessment of expert panel performance in core hospitals for cancer genomic medicine in Japan.
Int J Clin Oncol 2021;26:443-449.
PMID: 33385275
Liu X, Lu Y, Chen Z, Liu X, Hu W, Zheng L, Chen Y, Kurie JM, Shi M, Mustachio LM, Adresson T, Fox S, Roszik J, Kawakami M, Freemantle SJ, Dmitrovsky E.
The Ubiquitin-Specific Peptidase USP18 Promotes Lipolysis, Fatty Acid Oxidation, and Lung Cancer Growth.
Mol Cancer Res. 2021 Apr;19(4):667-677.
PMID: 33380466
Kawakami M, Mustachio LM, Chen Y, Chen Z, Liu X, Wei CH, Roszik J, Kittai AS, Danilov AV, Zhang X, Fang B, Wang J, Heymach JV, Tyutyunyk-Massey L, Freemantle SJ, Kurie JM, Liu X, Dmitrovsky E.
A Novel CDK2/9 Inhibitor CYC065 Causes Anaphase Catastrophe and Represses Proliferation, Tumorigenesis, and Metastasis in Aneuploid Cancers.
Mol Cancer Ther. 2021 Mar;20(3):477-489.
PMID: 33277443
--- 2020年 ---
Takeda K, Kawashima M, Masuda K, Kimura Y, Yamamoto S, Enomoto Y, Igei H, Ando T, Narumoto O, Morio Y, Matsui H.
Long-Term Outcomes of Bronchial Artery Embolization for Patients with Non-Mycobacterial Non-Fungal Infection Bronchiectasis.
Respiration. 2020;99(11):961-969.
PMID: 33264771
Horie M, Castaldi A, Sunohara M, Wang H, Ji Y, Liu Y, Li F, Wilkinson TA, Hung L, Shen H, Kage H, Offringa IA, Marconett CN, Flodby P, Zhou B, Borok Z.
Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker.
Cells. 2020 Nov 11;9(11):2460.
PMID: 33187367
Ando T, Kawashima M, Jo T, Masuda K, Yamauchi Y, Tanaka G, Kage H, Suzukawa M, Nagai H, Matsui H, Fushimi K, Yasunaga H, Nagase T.
Early Arterial Embolization and Mortality in Mechanically Ventilated Patients with Hemoptysis: A Nationwide Retrospective Cohort Study
Crit Care Med. 2020 Oct;48(10):1480-1486.
PMID: 32931191
Shinozaki-Ushiku A, Kohsaka S, Kage H, Oda K, Miyagawa K, Nakajima J, Aburatani H, Mano H, Ushiku T.
Genomic profiling of multiple primary cancers including synchronous lung adenocarcinoma and bilateral malignant mesotheliomas: Identification of a novel BAP1 germline variant.
Pathol Int. 2020 Oct;70(10):775-780.
PMID: 32583627
Yotsumoto T, Maemura K, Watanabe K, Amano Y, Matsumoto Y, Zokumasu K, Ando T, Kawakami M, Kage H, Nakajima J, Yatomi Y, Nagase T, Takai D.
NRXN1 as a novel potential target of antibody-drug conjugates for small cell lung cancer.
Oncotarget. 2020 Sep 29;11(39):3590-3600.
PMID: 33062195
Nilsson MB, Sun H, Robichaux J, Pfeifer M, Hofstad M, Kawakami M, Le X, Liu X, Fan Y, Poteete A, Hu L, Negrao MV, Tran H, Dmitrovsky E, Peng D, Gibbons DL, Wang J, Heymach JV.
A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components.
Sci Transl Med. 2020 Sep 2;12(559):eaaz4589.
PMID: 32878980
Okuma HA, Yonemori K, Noda-Narita S, Sukigara T, Hirakawa A, Shimizu T, Shibata T, Kawai A, Yamamoto N, Nakamura K, Nishida T, Fujiwara Y.
MASTER KEY Project: Powering Clinical Development for Rare Cancers Through a Platform Trial.
Clin Pharmacol Ther. 2020 Sep;108(3):596-605.
PMID: 32112563
Dmitrovsky E, Kawakami M, Liu XI, Freemantle SJ, Kurie JM.
TRIGGERING ANAPHASE CATASTROPHE TO COMBAT ANEUPLOID CANCERS.
Trans Am Clin Climatol Assoc. 2020;131:82-94.
PMID: 32675848
Watanabe K, Kage H, Nagoshi S, Toyama K, Ohno Y, Shinozaki-Ushiku A, Nakazaki K, Suzuki H, Kurokawa M, Nagase T.
Dual EGFR and ABL Tyrosine Kinase Inhibitor Treatment in a Patient with Concomitant EGFR-Mutated Lung Adenocarcinoma and
BCR-ABL1-Positive CML.
Case Rep Oncol Med. 2020 Mar 19;2020:4201727.
PMID: 32257476
Noda-Narita S, Shimomura A, Tanabe Y, Kawauchi J, Matsuzaki J, Takizawa S, Aoki Y, Shimizu C, Tamura K, Ochiya T.
Peripheral neuropathy from paclitaxel: risk prediction by serum microRNAs.
BMJ Support Palliat Care. 2020 Jan 14:bmjspcare-2019-001900.
PMID: 31937590
Ando T, Kage H, Matsumoto Y, Zokumasu K, Yotsumoto T, Maemura K, Amano Y, Watanabe K, Nakajima J, Nagase T, Takai D.
Integrin α11 in non-small cell lung cancer is associated with tumor progression and postoperative recurrence.
Cancer Sci. 2020 Jan;111(1):200-208.
PMID: 31778288
Kage H, Flodby P, Zhou B, Borok Z.
Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice.
Cell Mol Life Sci. 2019 Dec;76(23):4663-4672.
PMID: 31332482
Tateishi K, Ko R, Shukuya T, Okuma Y, Watanabe S, Kuyama S, Murase K, Tsukita Y, Ashinuma H, Nakagawa T, Uematsu K, Nakao M, Mori Y, Kaira K, Mouri A, Miyabayashi T, Sakashita H, Matsumoto Y, Tanigawa T, Koizumi T, Morita S, Kobayashi K, Nukiwa T, Takahashi K; North East Japan Study Group.
Clinical Outcomes of Second-Line Chemotherapy in Patients with Previously Treated Advanced Thymic Carcinoma: A Retrospective Analysis of 191 Patients from the NEJ023 Study.
Oncologist. 2019 Nov;24:1-7
PMID: 31771990
Zheng L, Chen Z, Kawakami M, Chen Y, Roszik J, Mustachio LM, Kurie JM, Villalobos P, Lu W, Behrens C, Mino B, Solis LM, Silvester J, Thu KL, Cescon DW, Rodriguez-Canales J, Wistuba II, Mak TW, Liu X, Dmitrovsky E.
Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy.
Mol Cancer Ther. 2019 Oct;18(10):1775-1786.
PMID: 31358662
Kage H, Kohsaka S, Shinozaki-Ushiku A, Hiraishi Y, Sato J, Nagayama K, Ushiku T, Takai D, Nakajima J, Miyagawa K, Aburatani H, Mano H, Nagase T.
Small lung tumor biopsy samples are feasible for high quality targeted next generation sequencing.
Cancer Sci. 2019 Aug;110(8):2652-2657.
PMID: 31222846
Noda-Narita S, Shimomura A, Kawachi A, Sumiyoshi-Okuma H, Sudo K, Shimoi T, Noguchi E, Yonemori K, Shimizu C, Fujiwara Y, Tamura K.
Comparison of the efficacy of trastuzumab emtansine between patients with metastatic human epidermal growth factor receptor 2-positive breast cancers previously treated with combination trastuzumab and pertuzumab and with trastuzumab only in Japanese population.
Breast Cancer. 2019 Jul;26(4):492-498
PMID: 30737616
Sawai Y, Katsuya Y, Shinozaki-Ushiku A, Iwasaki A, Fukayama M, Watanabe K, Nagase T.
Rapid temporal improvement of pembrolizumab-induced pneumonitis using the anti-TNF-α antibody infliximab.
Drug Discov Ther. 2019 Jul 22;13(3):164-167
PMID: 31257354
Saito A, Hakamata Y, Yamada Y, Sunohara M, Tarui M, Murano Y, Mitani A, Tanaka K, Nagase T, Yanagimoto S.
Pleural thickening on screening chest X-rays: a single institutional study.
Respir Res. 2019 Jul 5;20(1):138.
PMID: 31277661
Ando T, Kawashima M, Masuda K, Takeda K, Okuda K, Suzuki J, Ohshima N, Horibe M, Tamura A, Nagai H, Matsui H, Ohta K.
Exacerbation of chronic pulmonary aspergillosis was associated with a high rebleeding rate after bronchial artery embolization.
Respir Investig. 2019 May;57(3):260-267.
PMID: 30692051
Kohsaka S, Tatsuno K, Ueno T, Nagano M, Shinozaki-Ushiku A, Ushiku T, Takai D, Ikegami M, Kobayashi H, Kage H, Ando M, Hata K, Ueda H, Yamamoto S, Kojima S, Oseto K, Akaike K, Suehara Y, Hayashi T, Saito T, Takahashi F, Takahashi K, Takamochi K, Suzuki K, Nagayama S, Oda Y, Mimori K, Ishihara S, Yatomi Y, Nagase T, Nakajima J, Tanaka S, Fukayama M, Oda K, Nangaku M, Miyazono K, Miyagawa K, Aburatani H, Mano H.
Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens.
Cancer Sci. 2019 Apr;110(4):1464-1479.
PMID: 30737998
Ando T, Noguchi S, Enokida T, Yamato A, Kage H, Yamauchi Y, Okazaki A, Wakabayashi Y, Moriya K, Yamauchi H, Ono M, Nagase T.
Infectious Aneurysm Caused by Citrobacter koseri in an Immunocompetent Patient
Intern Med. 2019 Mar 15;58(6):813-816.
PMID: 30449805
Watanabe K, Kage H, Shinozaki-Ushiku A, Kohsaka S, Takai D, Nakajima J, Miyagawa K, Aburatani H, Mano H, Nagase T.
Spontaneous Transdifferentiation from Small Cell Lung Carcinoma to Squamous Cell Carcinoma.
J Thorac Oncol. 2019 Feb;14(2):e31-e34
PMID: 30683296
Saito M, Kage H, Ando T, Sawada R, Amano Y, Goto Y, Shinoda Y, Nagase T.
Prevalence of bone pain decreases as lymph node stage increases in nonsmall cell lung cancer patients.
Curr Probl Cancer. 2019 Feb;43(1):86-91.
PMID: 30195805
Abe M, Watanabe K, Shinozaki-Ushiku A, Ushiku T, Abe T, Fujihara Y, Amano Y, Zong L, Wang CP, Kubo E, Inaki R, Kinoshita N, Yamashita S, Takai D, Ushijima T, Nagase T, Hoshi K.
Identification of a metastatic lung adenocarcinoma of the palate mucosa through genetic and histopathological analysis: a rare case report and literature review.
BMC Cancer. 2019 Jan 11;19(1):52
PMID: 30634950
Noda-Narita S, Mizuno S, Noguchi S, Watanabe K, Nakai Y, Koike K, Kage H, Nagase T.
Development of mild drug-induced sclerosing cholangitis after discontinuation of nivolumab.
Eur J Cancer. 2019 Jan;107:93-96
PMID: 30554074
Kawakami M, Liu X, Dmitrovsky E.
New Cell Cycle Inhibitors Target Aneuploidy in Cancer Therapy.
Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:361-377.
PMID: 30110577
Maemura K, Watanabe K, Ando T, Hiyama N, Sakatani T, Amano Y, Kage H, Nakajima J, Yatomi Y, Nagase T, Takai D.
Altered editing level of microRNAs is a potential biomarker in lung adenocarcinoma.
Cancer Sci. 2018 Oct;109(10):3326-3335.
PMID: 30022565
Watanabe K, Yasumoto A, Amano Y, Kage H, Goto Y, Yatomi Y, Takai D, Nagase T.
Mean platelet volume and lymphocyte-to-monocyte ratio are associated with shorter progression-free survival in EGFR-mutant lung adenocarcinoma treated by EGFR tyrosine kinase inhibitor.
PLoS One. 2018 Sep 7;13(9):e0203625
PMID: 30192878
Chen L, Diao L, Yang Y, Yi X, Rodriguez BL, Li Y, Villalobos PA, Cascone T, Liu X, Tan L, Lorenzi PL, Huang A, Zhao Q, Peng D, Fradette JJ, Peng DH, Ungewiss C, Roybal J, Tong P, Oba J, Skoulidis F, Peng W, Carter BW, Gay CM, Fan Y, Class CA, Zhu J, Rodriguez-Canales J, Kawakami M, Byers LA, Woodman SE, Papadimitrakopoulou VA, Dmitrovsky E, Wang J, Ullrich SE, Wistuba II, Heymach JV, Qin FX, Gibbons DL.
CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade.
Cancer Discov. 2018 Sep;8(9):1156-1175.
PMID: 30012853
Yokoyama A, Kage H, Ohama Y, Sato T, Miyashita N, Noguchi S, Okugawa S, Yamauchi Y, Moriya K, Nagase T.
Mycobacterium heckeshornense lung infection diagnosed by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS).
J Infect Chemother. 2018 Sep;24(9):763-765.
PMID: 29503226
Ando T, Kage H, Saito M, Amano Y, Goto Y, Nakajima J, Nagase T.
Early stage non-small cell lung cancer patients need brain imaging regardless of symptoms.
Int J Clin Oncol. 2018 Aug;23(4):641-646.
PMID: 29484515
Kage H, Kohsaka S, Shinozaki-Ushiku A, Ushiku T, Takai D, Nakajima J, Miyagawa K, Aburatani H, Mano H, Nagase T.
Spontaneous Transformation from EGFR and ALK Wild-Type Lung Adenocarcinoma to Neuroendocrine Carcinoma.
J Thorac Oncol. 2018 Jul;13(7):e126-e128.
PMID: 29935853
Sakatani T, Amano Y, Sato J, Nagase T.
Air embolism after CT-guided percutaneous lung biopsy.
Jpn J Clin Oncol. 2018 Jul 1;48(7):699-700.
PMID: 29788435
Taniguchi Y, Matsumoto Y, Furukawa R, Ohara S, Usui K.
The clinical features of squamous cell lung carcinoma with sensitive EGFR mutations.
Int J Clin Oncol. 2018 Jun;23(3):452-457.
PMID: 29446042
Ando T, Kawashima M, Matsui H, Takeda K, Sato R, Ohshima N, Nagai H, Kitani M, Hebisawa A, Ohta K.
Clinical features and prognosis of nontuberculous mycobacterial pleuritis.
Respiration. 2018;96(6):507-513.
PMID: 30286448
Maemura K, Kage H, Isago H, Takeshima H, Makita K, Amano Y, Takai D, Ohishi N, Nagase T.
Cerebral Arterial Air Embolism after Diagnostic Flexible Fiberoptic Bronchoscopy: A Case Report and Review of the Literature.
Case Rep Pulmonol. 2018 May 7;2018:7108215.
PMID: 29854532
Noda-Narita S, Sumida K, Sekine A, Hoshino J, Mise K, Suwabe T, Hayami N, Yamanouchi M, Ueno T, Mizuno H, Kawada M, Hiramatsu R, Hasegawa E, Sawa N, Takaichi K, Ohashi K, Fujii T, Ubara Y.
TAFRO syndrome with refractory thrombocytopenia responding to tocilizumab and romiplostim: a case report.
CEN Case Rep. 2018 May;7(1):162-168
PMID: 29468524
Hiyama N, Ando T, Maemura K, Sakatani T, Amano Y, Watanabe K, Kage H, Yatomi Y, Nagase T, Nakajima J, Takai D.
Glutamate-cysteine ligase catalytic subunit is associated with cisplatin resistance in lung adenocarcinoma.
Jpn J Clin Oncol. 2018 Apr 1;48(4):303-307.
PMID: 29474642
Kawakami M, Mustachio LM, Liu X, Dmitrovsky E.
Engaging Anaphase Catastrophe Mechanisms to Eradicate Aneuploid Cancers.
Mol Cancer Ther. 2018 Apr;17(4):724-731.
PMID: 29559545
Zhou B, Flodby P, Luo J, Castillo DR, Liu Y, Yu FX, McConnell A, Varghese B, Li G, Chimge NO, Sunohara M, Koss MN, Elatre W, Conti P, Liebler JM, Yang C, Marconett CN, Laird-Offringa IA, Minoo P, Guan K, Stripp BR, Crandall ED, Borok Z.
Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis.
J Clin Invest. 2018 Mar 1;128(3):970-984.
PMID: 29400695
Kawakami M, Mustachio LM, Zheng L, Chen Y, Rodriguez-Canales J, Mino B, Kurie JM, Roszik J, Villalobos PA, Thu KL, Silvester J, Cescon DW, Wistuba II, Mak TW, Liu X, Dmitrovsky E.
Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers.
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1913-1918.
PMID: 29434041
Yanagiya M, Matsumoto J, Nagano M, Kusakabe M, Matsumoto Y, Furukawa R, Ohara S, Usui K.
Endoscopic bronchial occlusion for postoperative persistent bronchopleural fistula with computed tomography fluoroscopy guidance and virtual bronchoscopic navigation: A case report.
Medicine (Baltimore). 2018 Feb;97(7):e9921.
PMID: 29443771
Mustachio LM, Lu Y, Kawakami M, Roszik J, Freemantle SJ, Liu X, Dmitrovsky E.
Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target.
Cancer Res. 2018 Feb 1;78(3):587-592.
PMID: 29343520
Sato C, Okuda K, Tamiya H, Yamamoto K, Hoshina K, Narumoto O, Urushiyama H, Noguchi S, Amano Y, Watanabe K, Mitani A, Kage H, Tanaka G, Yamauchi Y, Takai D, Nagase T.
Acute Arterial Thrombosis during Postoperative Adjuvant Cisplatin-based Chemotherapy for Completely Resected Lung Adenocarcinoma.
Intern Med. 2018 Feb 15;57(4):557-561.
PMID: 29225246
Shinno Y, Kage H, Chino H, Inaba A, Arakawa S, Noguchi S, Amano Y, Yamauchi Y, Tanaka G, Nagase T.
Old age and underlying interstitial abnormalities are risk factors for development of ARDS after pleurodesis using limited amount of large particle size talc.
Respirology. 2018 Jan;23(1):55-59.
PMID: 28980363
Ando T, Kawashima M, Masuda K, Takeda K, Okuda K, Suzuki J, Ohshima N, Matsui H, Tamura A, Nagai H, Akagawa S, Ohta K.
Clinical and angiographic characteristics of 35 patients with cryptogenic hemoptysis.
Chest. 2017 Nov;152(5):1008-1014.
PMID: 28526654
Matsumoto Y, Ohara S, Furukawa R, Usui K.
The Prognosis of Small Cell Lung Cancer in Patients with Pulmonary Fibrosis.
Anticancer Res. 2017 Oct;37(10):5791-5795.
PMID: 28982903
Matsumoto Y, Miura T, Horiuchi H, Usui K.
The Successful Treatment of Pulmonary Pleomorphic Carcinoma with Pembrolizumab: A Case Report.
Case Rep Oncol. 2017 Aug 10;10(2):752-757.
PMID: 28878661
Sakatani T, Maemura K, Hiyama N, Amano Y, Watanabe K, Kage H, Fukayama M, Nakajima J, Yatomi Y, Nagase T, Takai D.
High expression of IRE1 in lung adenocarcinoma is associated with a lower rate of recurrence.
Jpn J Clin Oncol. 2017 Jun 1;47(6):543-550
PMID: 28334878
Kawakami M, Mustachio LM, Rodriguez-Canales J, Mino B, Roszik J, Tong P, Wang J, Lee JJ, Myung JH, Heymach JV, Johnson FM, Hong S, Zheng L, Hu S, Villalobos PA, Behrens C, Wistuba I, Freemantle S, Liu X, Dmitrovsky E.
Next-Generation CDK2/9 Inhibitors and Anaphase Catastrophe in Lung Cancer.
J Natl Cancer Inst. 2017 Jun 1;109(6).
PMID: 28376145
Mustachio LM, Lu Y, Tafe LJ, Memoli V, Rodriguez-Canales J, Mino B, Villalobos PA, Wistuba I, Katayama H, Hanash SM, Roszik J, Kawakami M, Cho KJ, Hancock JF, Chinyengetere F, Hu S, Liu X, Freemantle SJ, Dmitrovsky E.
Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer.
Mol Cancer Res. 2017 Jul;15(7):905-914.
PMID: 28242811
Arakawa S, Kage H, Chino H, Hinata M, Hayashi A, Toya T, Noguchi S, Ushiku T, Yamauchi Y, Kurokawa M, Fukayama M, Nagase T.
Reversion of serum VZV-IgG antibody preceding disseminated visceral varicella zoster after hematopoietic stem cell transplantation.
Ann Hematol. 2017 Mar;96(3):529-530.
PMID: 27844105
Marconett CN, Zhou B, Sunohara M, Pouldar TM, Wang H, Liu Y, Rieger ME, Tran E, Flodby P, Siegmund KD, Crandall ED,
Laird-Offringa IA, Borok Z.
Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes.
Am J Respir Cell Mol Biol. 2017 Mar;56(3):310-321.
PMID: 27749084
Mustachio LM, Kawakami M, Lu Y, Rodriguez-Canales J, Mino B, Behrens C, Wistuba I, Bota-Rabassedas N, Yu J, Lee JJ, Roszik J, Zheng L, Liu X, Freemantle SJ, Dmitrovsky E.
The ISG15-specific protease USP18 regulates stability of PTEN.
Oncotarget. 2017 Jan 3;8(1):3-14.
PMID: 27980214
Flodby P, Liebler JM, Sunohara M, Castillo DR, McConnell AM, Krishnaveni MS, Banfalvi A, Li M, Stripp B, Zhou B, Crandall ED, Minoo P, Borok Z.
Region-specific role for Pten in maintenance of epithelial phenotype and integrity.
Am J Physiol Lung Cell Mol Physiol. 2017 Jan 1;312(1):L131-L142.
PMID: 27864284
Danilov AV, Hu S, Orr B, Godek K, Mustachio LM, Sekula D, Liu X, Kawakami M, Johnson FM, Compton DA, Freemantle SJ,
Dmitrovsky E.
Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2.
Mol Cancer Ther. 2016 Nov;15(11):2758-2766.
PMID: 27550941
Kage H, Goto Y, Amano Y, Makita K, Isago H, Kobayashi K, Narumoto O, Okudaira R, Tanaka G, Takami K, Ohishi N, Nagase T.
Development of Pulmonary Artery Aneurysms Due to Behçet's Disease and Resolution after Treatment.
Intern Med. 2016;55(22):3337-3340.
PMID: 27853079
Flodby P, Kim YH, Beard LL, Gao D, Ji Y, Kage H, Liebler JM, Minoo P, Kim KJ, Borok Z, Crandall ED.
Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance.
Am J Respir Cell Mol Biol. 2016 Sep;55(3):395-406.
PMID: 27064541
Chino H, Amano Y, Yamauchi Y, Matsuda J, Takeda N, Tanaka G, Takai D, Nagase T.
Cardiogenic syncope possibly related to bevacizumab-containing combination chemotherapy for advanced non-small cell lung cancer.
J Thorac Dis. 2016 Sep;8(9):2646-2650.
PMID: 27747019
Noda S, Kanda S.
Addressing epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer.
Expert Rev Respir Med. 2016;10(5):547-556
PMID: 26959310
Rieger ME, Zhou B, Solomon N, Sunohara M, Li C, Nguyen C, Liu Y, Pan JH, Minoo P, Crandall ED, Brody SL, Kahn M, Borok Z.
p300/β-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC).
J Biol Chem. 2016 Mar 18;291(12):6569-82.
PMID: 26833564
Takeda K, Suzuki J, Nagai H, Watanabe K, Yokoyama A, Ando T, Suzuki J, Ohshima N, Masuda K, Tamura A, Akagawa S, Kitani M, Hebisawa A, Matsui H, Kobayashi N, Maruyama H, Ohta K.
Thoracoscopic examination of empyema in a patient with sparganosis mansoni.
J Infect Chemother. 2016 Feb;22(2):120-3.
PMID: 26603428
Takeda K, Ohshima N, Nagai H, Sato R, Ando T, Kusaka K, Kawashima M, Masuda K, Matsui H, Aono A, Chikamatsu K, Mitarai S,
Ohta K.
Six Cases of Pulmonary Mycobacterium shinjukuense Infection at a Single Hospital.
Intern Med. 2016;55(7):787-91.
PMID: 27041166
Ishikawa R, Amano Y, Kawakami M, Sunohara M, Watanabe K, Kage H, Ohishi N, Yatomi Y, Nakajima J, Fukayama M, Nagase T,
Takai D.
The chimeric transcript RUNX1-GLRX5: a biomarker for good postoperative prognosis in Stage IA non-small-cell lung cancer.
Jpn J Clin Oncol. 2016 Feb;46(2):185-9
PMID: 26685324
Okuda K, Masuda K, Kawashima M, Ando T, Koyama K, Ohshima N, Tamura A, Nagai H, Akagawa S, Matsui H, Ohta K.
Bronchial artery embolization to control hemoptysis in patients with Mycobacterium avium complex.
Respir Investig. 2016 Jan;54(1):50-8.
PMID: 26718145
Chinyengetere F, Sekula DJ, Lu Y, Giustini AJ, Sanglikar A, Kawakami M, Ma T, Burkett SS, Eisenberg BL, Wells WA, Hoopes PJ, Demicco EG, Lazar AJ, Torres KE, Memoli V, Freemantle SJ, Dmitrovsky E.
Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas.
BMC Cancer. 2015 Nov 10;15:886. doi: 10.1186/s12885-015-1883-8.
PMID: 26555296
Hu S, Lu Y, Orr B, Godek K, Mustachio LM, Kawakami M, Sekula D, Compton DA, Freemantle S, Dmitrovsky E.
Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.
Mol Cancer Ther. 2015 Nov;14(11):2576-85.
PMID: 26304236
Watanabe K, Amano Y, Ishikawa R, Sunohara M, Kage H, Ichinose J, Sano A, Nakajima J, Fukayama M, Yatomi Y, Nagase T, Ohishi N, Takai D.
Histone methylation-mediated silencing of miR-139 enhances invasion of non-small-cell lung cancer.
Cancer Med. 2015 Oct;4(10):1573-82
PMID: 26256448
Kage H, Flodby P, Gao D, Kim YH, Marconett CN, DeMaio L, Kim KJ, Crandall ED, Borok Z.
Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury.
Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L524-36.
PMID: 25106430
Li G, Flodby P, Luo J, Kage H, Sipos A, Gao D, Ji Y, Beard LL, Marconett CN, DeMaio L, Kim YH, Kim KJ, Laird-Offringa IA, Minoo P, Liebler JM, Zhou B, Crandall ED, Borok Z.
Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis.
Am J Respir Cell Mol Biol. 2014 Aug;51(2):210-22.
PMID: 24588076
Koyama K, Ohshima N, Suzuki J, Kawashima M, Takeda K, Ando T, Sato R, Nagai H, Matsui H, Ohta K.
Recurrence of chronic pulmonary aspergillosis after discontinuation of maintenance treatment by antifungal triazoles.
J Infect Chemother. 2014 Jun;20(6):375-9.
PMID: 24679654
Hasegawa W, Yamauchi Y, Yasunaga H, Sunohara M, Jo T, Matsui H, Fushimi K, Takami K, Nagase T.
Factors that predict in-hospital mortality in eosinophilic granulomatosis with polyangiitis.
Allergy. 2015 May;70(5):585-90.
PMID: 25703656
Ishibashi F, Sunohara M, Kawagoe S.
Performance of severity scores for home care-based patients suffering from pneumonia.
Geriatr Gerontol Int. 2015 Mar;15(3):311-7.
PMID: 24617550
Amano Y, Ishikawa R, Sakatani T, Ichinose J, Sunohara M, Watanabe K, Kage H, Nakajima J, Nagase T, Ohishi N, Takai D.
Oncogenic TPM3-ALK activation requires dimerization through the coiled-coil structure of TPM3.
Biochem Biophys Res Commun. 2015 Feb 13;457(3):457-60
PMID: 25596129
Hasegawa W, Yamauchi Y, Yasunaga H, Sunohara M, Jo T, Matsui H, Fushimi K, Takami K, Nagase T.
Clinical features of 280 hospitalized patients with lymphangioleiomyomatosis in Japan.
Respirology. 2015 Jan;20(1):160-5.
PMID: 25385157
Yamauchi Y, Hasegawa W, Yasunaga H, Sunohara M, Jo T, Takami K, Matsui H, Fushimi K, Nagase T.
Paradoxical association between body mass index and in-hospital mortality in elderly patients with chronic obstructive pulmonary disease in Japan.
Int J Chron Obstruct Pulmon Dis. 2014 Dec 9;9:1337-46.
PMID: 25525351
Ichinose J, Watanabe K, Sano A, Nagase T, Nakajima J, Fukayama M, Yatomi Y, Ohishi N, Takai D.
Alternative polyadenylation is associated with lower expression of PABPN1 and poor prognosis in non-small cell lung cancer.
Cancer Sci. 2014 Sep;105(9):1135-41
PMID: 24975429
Hasegawa W, Yamauchi Y, Yasunaga H, Sunohara M, Jo T, Matsui H, Fushimi K, Takami K, Nagase T.
Factors affecting mortality following emergency admission for chronic obstructive pulmonary disease.
BMC Pulm Med. 2014 Sep 24;14:151.
PMID: 25253449
Kassai H, Sugaya Y, Noda S, Nakao K, Maeda T, Kano M, Aiba A.
Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases.
Cell Rep. 2014 Jun 12;7(5):1626-1639
PMID: 24857653
Watanabe K, Takai D.
Disruption of the expression and function of microRNAs in lung cancer as a result of epigenetic changes.
Front Genet. 2013 Dec 3;4:275
PMID: 24348521
Amano Y, Takai D, Ohishi N, Shinozaki-Ushiku A, Fukayama M, Akahane M, Nakajima J, Nagase T.
Successful Treatment of Mediastinal Unicentric Castleman's Disease Using Video-Assisted Thoracoscopic Surgery with Preoperative Embolization.
Case Rep Med. 2013;2013:354507.
PMID: 24198836
Kawakami M, Ishikawa R, Amano Y, Sunohara M, Watanabe K, Ohishi N, Yatomi Y, Nakajima J, Fukayama M, Nagase T, Takai D.
Detection of novel paraja ring finger 2-fer tyrosine kinase mRNA chimeras is associated with poor postoperative prognosis in non-small cell lung cancer.
Cancer Sci. 2013 Nov;104(11):1447-54
PMID: 23931849
Kawakami M, Morita S, Sunohara M, Amano Y, Ishikawa R, Watanabe K, Hamano E, Ohishi N, Nakajima J, Yatomi Y, Nagase T, Fukayama M, Takai D.
FER overexpression is associated with poor postoperative prognosis and cancer-cell survival in non-small cell lung cancer.
Int J Clin Exp Pathol. 2013;6(4):598-612
PMID: 23573306
Isshiki T, Yamaguchi T, Yamada Y, Maemura K, Makita K, Takeshima H, Hirasawa Y, Yamaguchi Y, Hosoki K, Suzuki M, Kono C,
Terada J, Tatsumi K.
Usefulness of low-dose methotrexate monotherapy for treating sarcoidosis.
Intern Med. 2013;52(24):2727-32.
PMID: 24334575
Kage H, Borok Z.
EMT and interstitial lung disease: a mysterious relationship.
Curr Opin Pulm Med. 2012 Sep;18(5):517-23.
PMID: 22854509
Kitano K, Watanabe K, Emoto N, Kage H, Hamano E, Nagase T, Sano A, Murakawa T, Nakajima J, Goto A, Fukayama M, Yatomi Y, Ohishi N, Takai D.
CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer.
Cancer Sci. 2011 Dec;102(12):2126-31
PMID: 21917081
Kitagawa H, Watanabe K, Kage H, Inoh S, Goto A, Fukayama M, Nagase T, Ohishi N, Takai D.
Pulmonary venous invasion, determined by chest computed tomographic scan, as a potential early indicator of zygomycosis infection: a case series.
J Thorac Imaging. 2012 Jul;27(4):W97-9
PMID: 21912300
Watanabe K, Emoto N, Hamano E, Sunohara M, Kawakami M, Kage H, Kitano K, Nakajima J, Goto A, Fukayama M, Nagase T,
Yatomi Y, Ohishi N, Takai D.
Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer.
Int J Cancer. 2012 Jun1;130(11):2580-90
PMID: 21702040
Yamaguchi Y, Hibi S, Ishii M, Hanaoka Y, Kage H, Yamamoto H, Yamauchi Y, Eto M, Nagase T, Ouchi Y.
Pulmonary features associated with being underweight in older men.
J Am Geriatr Soc. 2011 Aug;59(8):1558-60.
PMID: 21848827
Sunohara M, Kawakami M, Kage H, Watanabe K, Emoto N, Nagase T, Ohishi N, Takai D.
Polymerase reaction without primers throughout for the reconstruction of full-length cDNA from products of rapid amplification of cDNA ends (RACE).
Biotechnol Lett. 2011 Jul;33(7):1301-7
PMID: 21384194
Kage H, Sugimoto K, Sano A, Kitagawa H, Nagase T, Ohishi N, Takai D.
Suppression of transforming growth factor β1 in lung alveolar epithelium-derived cells using adeno-associated virus type 2/5 vectors to carry short hairpin RNA.
Exp Lung Res. 2011 Apr;37(3):175-85.
PMID: 21269064
Watanabe K, Emoto N, Sunohara M, Kawakami M, Kage H, Nagase T, Ohishi N, Takai D.
Treatment of PCR products with exonuclease I and heat-labile alkaline phosphatase improves the visibility of combined bisulfite restriction analysis.
Biochem Biophys Res Commun. 2010 Aug 27;399(3):422-4
PMID: 20674551
Kusakabe M, Watanabe K, Emoto N, Aki N, Kage H, Nagase T, Nakajima J, Yatomi Y, Ohishi N, Takai D.
Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists.
Biochem Biophys Res Commun. 2009 Dec 25;390(4):1283-7
PMID: 19878646
Sunohara M, Hara K, Osamura K, Tashiro N, Shibuya H, Nakahara K, Kishida Y, Tamura K, Hisada T.
Mucosa associated lymphoid tissue (MALT) lymphoma of the thymus with trisomy 18.
Intern Med. 2009;48(23):2025-32.
PMID: 19952486
Kusakabe M, Kutomi T, Watanabe K, Emoto N, Aki N, Kage H, Hamano E, Kitagawa H, Nagase T, Sano A, Yoshida Y, Fukami T,
Murakawa T, Nakajima J, Takamoto S, Ota S, Fukayama M, Yatomi Y, Ohishi N, Takai D.
Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches.
Int J Cancer. 2010 Apr 15;126(8):1895-1902
PMID: 19816938
Kage H, Kohyama T, Kitagawa H, Takai D, Kanda Y, Ohishi N, Nagase T.
Non-infectious bronchiolitis as an early pulmonary complication of hematopoietic stem cell transplantation.
Intern Med. 2008;47(1):61-4.
PMID: 18176008
Sano A, Kage H, Sugimoto K, Kitagawa H, Aki N, Goto A, Fukayama M, Nakajima J, Takamoto S, Nagase T, Yatomi Y, Ohishi N,
Takai D.
A second-generation profiling system for quantitative methylation analysis of multiple gene promoters: application to lung cancer.
Oncogene. 2007 Oct 4;26(45):6518-25.
PMID: 17452971
Sugimoto K, Kage H, Aki N, Sano A, Kitagawa H, Nagase T, Yatomi Y, Ohishi N, Takai D.
The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus.
Biochem Biophys Res Commun. 2007 Aug 3;359(3):497-502.
PMID: 17544373
