呼吸器内科305研究室では、呼吸器疾患を分子生物学の言葉で記述するべく、様々な手法を用いて、主に肺癌の研究を行っています。

メンバー紹介

氏 名職 名
鹿毛 秀宣Kage Hidenori次世代プレシジョンメディシン開発講座 特任准教授
川上 正敬Kawakami Masanori呼吸器内科 特任講師(病院)
江本 範子Emoto Noriko保健・健康推進本部 助教
渡邊 広祐Watanabe Kousuke検査部 講師
春原 光宏Sunohara Mitsuhiro保健・健康推進本部 講師
前村 啓太Maemura Keita呼吸器内科 助教
安藤 孝浩Ando Takahiro呼吸器内科 助教
成田 翔子Narita Shoko動物資源学 助教
松本 容子Matsumoto Yoko届出研究員


最近の出版論文

--- 2021年 ---

Sunami K, Naito Y, Aimono E, Amano T, Ennishi D, Kage H, Kanai M, Komine K, Koyama T, Maeda T, Morita S, Sakai D, Kohsaka S, Tsuchihara K, Yoshino T.
The initial assessment of expert panel performance in core hospitals for cancer genomic medicine in Japan.
Int J Clin Oncol. 2021 Online ahead of print.
PMID: 33385275


--- 2020年 ---

Horie M, Castaldi A, Sunohara M, Wang H, Ji Y, Liu Y, Li F, Wilkinson TA, Hung L, Shen H, Kage H, Offringa IA, Marconett CN, Flodby P, Zhou B, Borok Z.
Integrated Single-Cell RNA-Sequencing Analysis of Aquaporin 5-Expressing Mouse Lung Epithelial Cells Identifies GPRC5A as a Novel Validated Type I Cell Surface Marker.
Cells. 2020 Nov 11;9(11):2460.
PMID: 33187367

Genomic profiling of multiple primary cancers including synchronous lung adenocarcinoma and bilateral malignant mesotheliomas: Identification of a novel BAP1 germline variant.
Pathol Int. 2020 Oct;70(10):775-780.
PMID: 32583627

Early Arterial Embolization and Mortality in Mechanically Ventilated Patients with Hemoptysis: A Nationwide Retrospective Cohort Study
Crit Care Med. 2020 Oct;48(10):1480-1486. doi: 10.1097/CCM.0000000000004513.
PMID: 3293119

Yotsumoto T, Maemura K, Watanabe K, Amano Y, Matsumoto Y, Zokumasu K, Ando T, Kawakami M, Kage H, Nakajima J, Yatomi Y,
Nagase T, Takai D.
NRXN1 as a novel potential target of antibody-drug conjugates for small cell lung cancer.
Oncotarget. 2020 Sep 29;11(39):3590-3600. doi: 10.18632/oncotarget.27718.
PMID: 33062195; PMCID: PMC7533074.

MASTER KEY Project: Powering Clinical Development for Rare Cancers Through a Platform Trial.
Clin Pharmacol Ther. 2020 Sep;108(3):596-605.
PMID: 32112563

Watanabe K, Kage H, Nagoshi S, Toyama K, Ohno Y, Shinozaki-Ushiku A, Nakazaki K, Suzuki H, Kurokawa M, Nagase T.
Dual EGFR and ABL Tyrosine Kinase Inhibitor Treatment in a Patient with Concomitant EGFR-Mutated Lung Adenocarcinoma and
BCR-ABL1-Positive CML.
Case Rep Oncol Med. 2020 Mar 19;2020:4201727.
PMID: 32257476

Okuma HA, Yonemori K, Narita SN, Sukigara T, Hirakawa A, Shimizu T, Shibata T, Kawai A, Yamamoto N, Nakamura K, Nishida T, Fujiwara Y.
MASTER KEY Project: Powering Clinical Development for Rare Cancers Through a Platform Trial.
Clin Pharmacol Ther. 2020 Feb 29. [Epub ahead of print]
PMID: 32112563

Shinozaki-Ushiku A, Kohsaka S, Kage H, Oda K, Miyagawa K, Nakajima J, Aburatani H, Mano H, Ushiku T.
Genomic profiling of multiple primary cancers including synchronous lung adenocarcinoma and bilateral malignant mesotheliomas: Identification of a novel BAP1 germline variant.
Pathol Int. 2020 Jun 24. Online ahead of print.
PMID: 32583627

Ando T, Kawashima M, Jo T, Masuda K, Yamauchi Y, Tanaka G, Kage H, Suzukawa M, Nagai H, Matsui H, Fushimi K, Yasunaga H, Nagase T.
Early Arterial Embolization and Mortality in Mechanically Ventilated Patients with Hemoptysis: A Nationwide Retrospective Cohort Study
Crit Care Med. (in press)

Noda-Narita S, Shimomura A, Tanabe Y, Kawauchi J, Matsuzaki J, Takizawa S, Aoki Y, Shimizu C, Tamura K, Ochiya T.
Peripheral neuropathy from paclitaxel: risk prediction by serum microRNAs.
BMJ Support Palliat Care. 2020 Jan 14. [Epub ahead of print]
PMID: 31937590

Ando T, Kage H, Matsumoto Y, Zokumasu K, Yotsumoto T, Maemura K, Amano Y, Watanabe K, Nakajima J, Nagase T, Takai D.
Integrin α11 in non-small cell lung cancer is associated with tumor progression and postoperative recurrence.
Cancer Sci. 2020 Jan;111(1):200-208.
PMID: 31778288


--- 2019年 ---

Kage H, Flodby P, Zhou B, Borok Z.
Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice.
Cell Mol Life Sci. 2019 Dec;76(23):4663-4672.
PMID: 31332482

Tateishi K, Ko R, Shukuya T, Okuma Y, Watanabe S, Kuyama S, Murase K, Tsukita Y, Ashinuma H, Nakagawa T, Uematsu K, Nakao M, Mori Y, Kaira K, Mouri A, Miyabayashi T, Sakashita H, Matsumoto Y, Tanigawa T, Koizumi T, Morita S, Kobayashi K, Nukiwa T, Takahashi K; North East Japan Study Group.
Clinical Outcomes of Second-Line Chemotherapy in Patients with Previously Treated Advanced Thymic Carcinoma: A Retrospective Analysis of 191 Patients from the NEJ023 Study.
Oncologist. 2019 Nov;24:1-7
PMID: 31771990

Zheng L, Chen Z, Kawakami M, Chen Y, Roszik J, Mustachio LM, Kurie JM, Villalobos P, Lu W, Behrens C, Mino B, Solis LM, Silvester J, Thu KL, Cescon DW, Rodriguez-Canales J, Wistuba II, Mak TW, Liu X, Dmitrovsky E.
Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy.
Mol Cancer Ther. 2019 Oct;18(10):1775-1786.
PMID: 31358662

Kage H, Kohsaka S, Shinozaki-Ushiku A, Hiraishi Y, Sato J, Nagayama K, Ushiku T, Takai D, Nakajima J, Miyagawa K, Aburatani H, Mano H, Nagase T.
Small lung tumor biopsy samples are feasible for high quality targeted next generation sequencing.
Cancer Sci. 2019 Aug;110(8):2652-2657.
PMID: 31222846

Noda-Narita S, Shimomura A, Kawachi A, Sumiyoshi-Okuma H, Sudo K, Shimoi T, Noguchi E, Yonemori K, Shimizu C, Fujiwara Y, Tamura K.
Comparison of the efficacy of trastuzumab emtansine between patients with metastatic human epidermal growth factor receptor 2-positive breast cancers previously treated with combination trastuzumab and pertuzumab and with trastuzumab only in Japanese population.
Breast Cancer. 2019 Jul;26(4):492-498
PMID: 30737616

Sawai Y, Katsuya Y, Shinozaki-Ushiku A, Iwasaki A, Fukayama M, Watanabe K, Nagase T.
Rapid temporal improvement of pembrolizumab-induced pneumonitis using the anti-TNF-α antibody infliximab.
Drug Discov Ther. 2019 Jul 22;13(3):164-167
PMID: 31257354

Saito A, Hakamata Y, Yamada Y, Sunohara M, Tarui M, Murano Y, Mitani A, Tanaka K, Nagase T, Yanagimoto S.
Pleural thickening on screening chest X-rays: a single institutional study.
Respir Res. 2019 Jul 5;20(1):138.
PMID: 31277661

Ando T, Kawashima M, Masuda K, Takeda K, Okuda K, Suzuki J, Ohshima N, Horibe M, Tamura A, Nagai H, Matsui H, Ohta K.
Exacerbation of chronic pulmonary aspergillosis was associated with a high rebleeding rate after bronchial artery embolization.
Respir Investig. 2019 May;57(3):260-267.
PMID: 30692051

Kohsaka S, Tatsuno K, Ueno T, Nagano M, Shinozaki-Ushiku A, Ushiku T, Takai D, Ikegami M, Kobayashi H, Kage H, Ando M, Hata K, Ueda H, Yamamoto S, Kojima S, Oseto K, Akaike K, Suehara Y, Hayashi T, Saito T, Takahashi F, Takahashi K, Takamochi K, Suzuki K, Nagayama S, Oda Y, Mimori K, Ishihara S, Yatomi Y, Nagase T, Nakajima J, Tanaka S, Fukayama M, Oda K, Nangaku M, Miyazono K, Miyagawa K, Aburatani H, Mano H.
Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens.
Cancer Sci. 2019 Apr;110(4):1464-1479.
PMID: 30737998

Ando T, Noguchi S, Enokida T, Yamato A, Kage H, Yamauchi Y, Okazaki A, Wakabayashi Y, Moriya K, Yamauchi H, Ono M, Nagase T.
Infectious Aneurysm Caused by Citrobacter koseri in an Immunocompetent Patient
Intern Med. 2019 Mar 15;58(6):813-816.
PMID: 30449805

Watanabe K, Kage H, Shinozaki-Ushiku A, Kohsaka S, Takai D, Nakajima J, Miyagawa K, Aburatani H, Mano H, Nagase T.
Spontaneous Transdifferentiation from Small Cell Lung Carcinoma to Squamous Cell Carcinoma.
J Thorac Oncol. 2019 Feb;14(2):e31-e34
PMID: 30683296

Saito M, Kage H, Ando T, Sawada R, Amano Y, Goto Y, Shinoda Y, Nagase T.
Prevalence of bone pain decreases as lymph node stage increases in nonsmall cell lung cancer patients.
Curr Probl Cancer. 2019 Feb;43(1):86-91.
PMID: 30195805

Abe M, Watanabe K, Shinozaki-Ushiku A, Ushiku T, Abe T, Fujihara Y, Amano Y, Zong L, Wang CP, Kubo E, Inaki R, Kinoshita N, Yamashita S, Takai D, Ushijima T, Nagase T, Hoshi K.
Identification of a metastatic lung adenocarcinoma of the palate mucosa through genetic and histopathological analysis: a rare case report and literature review.
BMC Cancer. 2019 Jan 11;19(1):52
PMID: 30634950

Noda-Narita S, Mizuno S, Noguchi S, Watanabe K, Nakai Y, Koike K, Kage H, Nagase T.
Development of mild drug-induced sclerosing cholangitis after discontinuation of nivolumab.
Eur J Cancer. 2019 Jan;107:93-96
PMID: 30554074

Kawakami M, Liu X, Dmitrovsky E.
New Cell Cycle Inhibitors Target Aneuploidy in Cancer Therapy.
Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:361-377.
PMID: 30110577


--- 2018年 ---

Maemura K, Watanabe K, Ando T, Hiyama N, Sakatani T, Amano Y, Kage H, Nakajima J, Yatomi Y, Nagase T, Takai D.
Altered editing level of microRNAs is a potential biomarker in lung adenocarcinoma.
Cancer Sci. 2018 Oct;109(10):3326-3335.
PMID: 30022565

Watanabe K, Yasumoto A, Amano Y, Kage H, Goto Y, Yatomi Y, Takai D, Nagase T.
Mean platelet volume and lymphocyte-to-monocyte ratio are associated with shorter progression-free survival in EGFR-mutant lung adenocarcinoma treated by EGFR tyrosine kinase inhibitor.
PLoS One. 2018 Sep 7;13(9):e0203625
PMID: 30192878

Chen L, Diao L, Yang Y, Yi X, Rodriguez BL, Li Y, Villalobos PA, Cascone T, Liu X, Tan L, Lorenzi PL, Huang A, Zhao Q, Peng D, Fradette JJ, Peng DH, Ungewiss C, Roybal J, Tong P, Oba J, Skoulidis F, Peng W, Carter BW, Gay CM, Fan Y, Class CA, Zhu J, Rodriguez-Canales J, Kawakami M, Byers LA, Woodman SE, Papadimitrakopoulou VA, Dmitrovsky E, Wang J, Ullrich SE, Wistuba II, Heymach JV, Qin FX, Gibbons DL.
CD38-Mediated Immunosuppression as a Mechanism of Tumor Cell Escape from PD-1/PD-L1 Blockade.
Cancer Discov. 2018 Sep;8(9):1156-1175.
PMID: 30012853

Yokoyama A, Kage H, Ohama Y, Sato T, Miyashita N, Noguchi S, Okugawa S, Yamauchi Y, Moriya K, Nagase T.
Mycobacterium heckeshornense lung infection diagnosed by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS).
J Infect Chemother. 2018 Sep;24(9):763-765.
PMID: 29503226

Ando T, Kage H, Saito M, Amano Y, Goto Y, Nakajima J, Nagase T.
Early stage non-small cell lung cancer patients need brain imaging regardless of symptoms.
Int J Clin Oncol. 2018 Aug;23(4):641-646.
PMID: 29484515

Kage H, Kohsaka S, Shinozaki-Ushiku A, Ushiku T, Takai D, Nakajima J, Miyagawa K, Aburatani H, Mano H, Nagase T.
Spontaneous Transformation from EGFR and ALK Wild-Type Lung Adenocarcinoma to Neuroendocrine Carcinoma.
J Thorac Oncol. 2018 Jul;13(7):e126-e128.
PMID: 29935853

Sakatani T, Amano Y, Sato J, Nagase T.
Air embolism after CT-guided percutaneous lung biopsy.
Jpn J Clin Oncol. 2018 Jul 1;48(7):699-700.
PMID: 29788435

Taniguchi Y, Matsumoto Y, Furukawa R, Ohara S, Usui K.
The clinical features of squamous cell lung carcinoma with sensitive EGFR mutations.
Int J Clin Oncol. 2018 Jun;23(3):452-457.
PMID: 29446042

Ando T, Kawashima M, Matsui H, Takeda K, Sato R, Ohshima N, Nagai H, Kitani M, Hebisawa A, Ohta K.
Clinical features and prognosis of nontuberculous mycobacterial pleuritis.
Respiration. 2018;96(6):507-513.
PMID: 30286448

Maemura K, Kage H, Isago H, Takeshima H, Makita K, Amano Y, Takai D, Ohishi N, Nagase T.
Cerebral Arterial Air Embolism after Diagnostic Flexible Fiberoptic Bronchoscopy: A Case Report and Review of the Literature.
Case Rep Pulmonol. 2018 May 7;2018:7108215.
PMID: 29854532

Noda-Narita S, Sumida K, Sekine A, Hoshino J, Mise K, Suwabe T, Hayami N, Yamanouchi M, Ueno T, Mizuno H, Kawada M, Hiramatsu R, Hasegawa E, Sawa N, Takaichi K, Ohashi K, Fujii T, Ubara Y.
TAFRO syndrome with refractory thrombocytopenia responding to tocilizumab and romiplostim: a case report.
CEN Case Rep. 2018 May;7(1):162-168
PMID: 29468524

Hiyama N, Ando T, Maemura K, Sakatani T, Amano Y, Watanabe K, Kage H, Yatomi Y, Nagase T, Nakajima J, Takai D.
Glutamate-cysteine ligase catalytic subunit is associated with cisplatin resistance in lung adenocarcinoma.
Jpn J Clin Oncol. 2018 Apr 1;48(4):303-307.
PMID: 29474642

Kawakami M, Mustachio LM, Liu X, Dmitrovsky E.
Engaging Anaphase Catastrophe Mechanisms to Eradicate Aneuploid Cancers.
Mol Cancer Ther. 2018 Apr;17(4):724-731.
PMID: 29559545

Zhou B, Flodby P, Luo J, Castillo DR, Liu Y, Yu FX, McConnell A, Varghese B, Li G, Chimge NO, Sunohara M, Koss MN, Elatre W, Conti P, Liebler JM, Yang C, Marconett CN, Laird-Offringa IA, Minoo P, Guan K, Stripp BR, Crandall ED, Borok Z.
Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis.
J Clin Invest. 2018 Mar 1;128(3):970-984.
PMID: 29400695

Kawakami M, Mustachio LM, Zheng L, Chen Y, Rodriguez-Canales J, Mino B, Kurie JM, Roszik J, Villalobos PA, Thu KL, Silvester J, Cescon DW, Wistuba II, Mak TW, Liu X, Dmitrovsky E.
Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers.
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1913-1918.
PMID: 29434041

Yanagiya M, Matsumoto J, Nagano M, Kusakabe M, Matsumoto Y, Furukawa R, Ohara S, Usui K.
Endoscopic bronchial occlusion for postoperative persistent bronchopleural fistula with computed tomography fluoroscopy guidance and virtual bronchoscopic navigation: A case report.
Medicine (Baltimore). 2018 Feb;97(7):e9921.
PMID: 29443771

Mustachio LM, Lu Y, Kawakami M, Roszik J, Freemantle SJ, Liu X, Dmitrovsky E.
Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target.
Cancer Res. 2018 Feb 1;78(3):587-592.
PMID: 29343520

Sato C, Okuda K, Tamiya H, Yamamoto K, Hoshina K, Narumoto O, Urushiyama H, Noguchi S, Amano Y, Watanabe K, Mitani A, Kage H, Tanaka G, Yamauchi Y, Takai D, Nagase T.
Acute Arterial Thrombosis during Postoperative Adjuvant Cisplatin-based Chemotherapy for Completely Resected Lung Adenocarcinoma.
Intern Med. 2018 Feb 15;57(4):557-561.
PMID: 29225246

Shinno Y, Kage H, Chino H, Inaba A, Arakawa S, Noguchi S, Amano Y, Yamauchi Y, Tanaka G, Nagase T.
Old age and underlying interstitial abnormalities are risk factors for development of ARDS after pleurodesis using limited amount of large particle size talc.
Respirology. 2018 Jan;23(1):55-59.
PMID: 28980363


--- 2017年 ---

Ando T, Kawashima M, Masuda K, Takeda K, Okuda K, Suzuki J, Ohshima N, Matsui H, Tamura A, Nagai H, Akagawa S, Ohta K.
Clinical and angiographic characteristics of 35 patients with cryptogenic hemoptysis.
Chest. 2017 Nov;152(5):1008-1014.
PMID: 28526654

Matsumoto Y, Ohara S, Furukawa R, Usui K.
The Prognosis of Small Cell Lung Cancer in Patients with Pulmonary Fibrosis.
Anticancer Res. 2017 Oct;37(10):5791-5795.
PMID: 28982903

Matsumoto Y, Miura T, Horiuchi H, Usui K.
The Successful Treatment of Pulmonary Pleomorphic Carcinoma with Pembrolizumab: A Case Report.
Case Rep Oncol. 2017 Aug 10;10(2):752-757.
PMID: 28878661

Sakatani T, Maemura K, Hiyama N, Amano Y, Watanabe K, Kage H, Fukayama M, Nakajima J, Yatomi Y, Nagase T, Takai D.
High expression of IRE1 in lung adenocarcinoma is associated with a lower rate of recurrence.
Jpn J Clin Oncol. 2017 Jun 1;47(6):543-550
PMID: 28334878

Kawakami M, Mustachio LM, Rodriguez-Canales J, Mino B, Roszik J, Tong P, Wang J, Lee JJ, Myung JH, Heymach JV, Johnson FM, Hong S, Zheng L, Hu S, Villalobos PA, Behrens C, Wistuba I, Freemantle S, Liu X, Dmitrovsky E.
Next-Generation CDK2/9 Inhibitors and Anaphase Catastrophe in Lung Cancer.
J Natl Cancer Inst. 2017 Jun 1;109(6).
PMID: 28376145

Mustachio LM, Lu Y, Tafe LJ, Memoli V, Rodriguez-Canales J, Mino B, Villalobos PA, Wistuba I, Katayama H, Hanash SM, Roszik J, Kawakami M, Cho KJ, Hancock JF, Chinyengetere F, Hu S, Liu X, Freemantle SJ, Dmitrovsky E.
Deubiquitinase USP18 Loss Mislocalizes and Destabilizes KRAS in Lung Cancer.
Mol Cancer Res. 2017 Jul;15(7):905-914.
PMID: 28242811

Arakawa S, Kage H, Chino H, Hinata M, Hayashi A, Toya T, Noguchi S, Ushiku T, Yamauchi Y, Kurokawa M, Fukayama M, Nagase T.
Reversion of serum VZV-IgG antibody preceding disseminated visceral varicella zoster after hematopoietic stem cell transplantation.
Ann Hematol. 2017 Mar;96(3):529-530.
PMID: 27844105

Marconett CN, Zhou B, Sunohara M, Pouldar TM, Wang H, Liu Y, Rieger ME, Tran E, Flodby P, Siegmund KD, Crandall ED,
Laird-Offringa IA, Borok Z.
Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes.
Am J Respir Cell Mol Biol. 2017 Mar;56(3):310-321.
PMID: 27749084

Mustachio LM, Kawakami M, Lu Y, Rodriguez-Canales J, Mino B, Behrens C, Wistuba I, Bota-Rabassedas N, Yu J, Lee JJ, Roszik J, Zheng L, Liu X, Freemantle SJ, Dmitrovsky E.
The ISG15-specific protease USP18 regulates stability of PTEN.
Oncotarget. 2017 Jan 3;8(1):3-14.
PMID: 27980214

Flodby P, Liebler JM, Sunohara M, Castillo DR, McConnell AM, Krishnaveni MS, Banfalvi A, Li M, Stripp B, Zhou B, Crandall ED, Minoo P, Borok Z.
Region-specific role for Pten in maintenance of epithelial phenotype and integrity.
Am J Physiol Lung Cell Mol Physiol. 2017 Jan 1;312(1):L131-L142.
PMID: 27864284


--- 2016年 ---

Danilov AV, Hu S, Orr B, Godek K, Mustachio LM, Sekula D, Liu X, Kawakami M, Johnson FM, Compton DA, Freemantle SJ,
Dmitrovsky E.
Dinaciclib Induces Anaphase Catastrophe in Lung Cancer Cells via Inhibition of Cyclin-Dependent Kinases 1 and 2.
Mol Cancer Ther. 2016 Nov;15(11):2758-2766.
PMID: 27550941

Kage H, Goto Y, Amano Y, Makita K, Isago H, Kobayashi K, Narumoto O, Okudaira R, Tanaka G, Takami K, Ohishi N, Nagase T.
Development of Pulmonary Artery Aneurysms Due to Behçet's Disease and Resolution after Treatment.
Intern Med. 2016;55(22):3337-3340.
PMID: 27853079

Flodby P, Kim YH, Beard LL, Gao D, Ji Y, Kage H, Liebler JM, Minoo P, Kim KJ, Borok Z, Crandall ED.
Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance.
Am J Respir Cell Mol Biol. 2016 Sep;55(3):395-406.
PMID: 27064541

Chino H, Amano Y, Yamauchi Y, Matsuda J, Takeda N, Tanaka G, Takai D, Nagase T.
Cardiogenic syncope possibly related to bevacizumab-containing combination chemotherapy for advanced non-small cell lung cancer.
J Thorac Dis. 2016 Sep;8(9):2646-2650.
PMID: 27747019

Noda S, Kanda S.
Addressing epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small cell lung cancer.
Expert Rev Respir Med. 2016;10(5):547-556
PMID: 26959310

Rieger ME, Zhou B, Solomon N, Sunohara M, Li C, Nguyen C, Liu Y, Pan JH, Minoo P, Crandall ED, Brody SL, Kahn M, Borok Z.
p300/β-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC).
J Biol Chem. 2016 Mar 18;291(12):6569-82.
PMID: 26833564

Takeda K, Suzuki J, Nagai H, Watanabe K, Yokoyama A, Ando T, Suzuki J, Ohshima N, Masuda K, Tamura A, Akagawa S, Kitani M, Hebisawa A, Matsui H, Kobayashi N, Maruyama H, Ohta K.
Thoracoscopic examination of empyema in a patient with sparganosis mansoni.
J Infect Chemother. 2016 Feb;22(2):120-3.
PMID: 26603428

Takeda K, Ohshima N, Nagai H, Sato R, Ando T, Kusaka K, Kawashima M, Masuda K, Matsui H, Aono A, Chikamatsu K, Mitarai S,
Ohta K.
Six Cases of Pulmonary Mycobacterium shinjukuense Infection at a Single Hospital.
Intern Med. 2016;55(7):787-91.
PMID: 27041166

Ishikawa R, Amano Y, Kawakami M, Sunohara M, Watanabe K, Kage H, Ohishi N, Yatomi Y, Nakajima J, Fukayama M, Nagase T,
Takai D.
The chimeric transcript RUNX1-GLRX5: a biomarker for good postoperative prognosis in Stage IA non-small-cell lung cancer.
Jpn J Clin Oncol. 2016 Feb;46(2):185-9
PMID: 26685324

Okuda K, Masuda K, Kawashima M, Ando T, Koyama K, Ohshima N, Tamura A, Nagai H, Akagawa S, Matsui H, Ohta K.
Bronchial artery embolization to control hemoptysis in patients with Mycobacterium avium complex.
Respir Investig. 2016 Jan;54(1):50-8.
PMID: 26718145


--- 2015年以前 ---

Chinyengetere F, Sekula DJ, Lu Y, Giustini AJ, Sanglikar A, Kawakami M, Ma T, Burkett SS, Eisenberg BL, Wells WA, Hoopes PJ, Demicco EG, Lazar AJ, Torres KE, Memoli V, Freemantle SJ, Dmitrovsky E.
Mice null for the deubiquitinase USP18 spontaneously develop leiomyosarcomas.
BMC Cancer. 2015 Nov 10;15:886. doi: 10.1186/s12885-015-1883-8.
PMID: 26555296

Hu S, Lu Y, Orr B, Godek K, Mustachio LM, Kawakami M, Sekula D, Compton DA, Freemantle S, Dmitrovsky E.
Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.
Mol Cancer Ther. 2015 Nov;14(11):2576-85.
PMID: 26304236

Watanabe K, Amano Y, Ishikawa R, Sunohara M, Kage H, Ichinose J, Sano A, Nakajima J, Fukayama M, Yatomi Y, Nagase T, Ohishi N, Takai D.
Histone methylation-mediated silencing of miR-139 enhances invasion of non-small-cell lung cancer.
Cancer Med. 2015 Oct;4(10):1573-82
PMID: 26256448

Kage H, Flodby P, Gao D, Kim YH, Marconett CN, DeMaio L, Kim KJ, Crandall ED, Borok Z.
Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury.
Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L524-36.
PMID: 25106430

Li G, Flodby P, Luo J, Kage H, Sipos A, Gao D, Ji Y, Beard LL, Marconett CN, DeMaio L, Kim YH, Kim KJ, Laird-Offringa IA, Minoo P, Liebler JM, Zhou B, Crandall ED, Borok Z.
Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis.
Am J Respir Cell Mol Biol. 2014 Aug;51(2):210-22.
PMID: 24588076

Koyama K, Ohshima N, Suzuki J, Kawashima M, Takeda K, Ando T, Sato R, Nagai H, Matsui H, Ohta K.
Recurrence of chronic pulmonary aspergillosis after discontinuation of maintenance treatment by antifungal triazoles.
J Infect Chemother. 2014 Jun;20(6):375-9.
PMID: 24679654

Hasegawa W, Yamauchi Y, Yasunaga H, Sunohara M, Jo T, Matsui H, Fushimi K, Takami K, Nagase T.
Factors that predict in-hospital mortality in eosinophilic granulomatosis with polyangiitis.
Allergy. 2015 May;70(5):585-90.
PMID: 25703656

Ishibashi F, Sunohara M, Kawagoe S.
Performance of severity scores for home care-based patients suffering from pneumonia.
Geriatr Gerontol Int. 2015 Mar;15(3):311-7.
PMID: 24617550

Amano Y, Ishikawa R, Sakatani T, Ichinose J, Sunohara M, Watanabe K, Kage H, Nakajima J, Nagase T, Ohishi N, Takai D.
Oncogenic TPM3-ALK activation requires dimerization through the coiled-coil structure of TPM3.
Biochem Biophys Res Commun. 2015 Feb 13;457(3):457-60
PMID: 25596129

Hasegawa W, Yamauchi Y, Yasunaga H, Sunohara M, Jo T, Matsui H, Fushimi K, Takami K, Nagase T.
Clinical features of 280 hospitalized patients with lymphangioleiomyomatosis in Japan.
Respirology. 2015 Jan;20(1):160-5.
PMID: 25385157

Yamauchi Y, Hasegawa W, Yasunaga H, Sunohara M, Jo T, Takami K, Matsui H, Fushimi K, Nagase T.
Paradoxical association between body mass index and in-hospital mortality in elderly patients with chronic obstructive pulmonary disease in Japan.
Int J Chron Obstruct Pulmon Dis. 2014 Dec 9;9:1337-46.
PMID: 25525351

Ichinose J, Watanabe K, Sano A, Nagase T, Nakajima J, Fukayama M, Yatomi Y, Ohishi N, Takai D.
Alternative polyadenylation is associated with lower expression of PABPN1 and poor prognosis in non-small cell lung cancer.
Cancer Sci. 2014 Sep;105(9):1135-41
PMID: 24975429

Hasegawa W, Yamauchi Y, Yasunaga H, Sunohara M, Jo T, Matsui H, Fushimi K, Takami K, Nagase T.
Factors affecting mortality following emergency admission for chronic obstructive pulmonary disease.
BMC Pulm Med. 2014 Sep 24;14:151.
PMID: 25253449

Kassai H, Sugaya Y, Noda S, Nakao K, Maeda T, Kano M, Aiba A.
Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases.
Cell Rep. 2014 Jun 12;7(5):1626-1639
PMID: 24857653

Watanabe K, Takai D.
Disruption of the expression and function of microRNAs in lung cancer as a result of epigenetic changes.
Front Genet. 2013 Dec 3;4:275
PMID: 24348521

Amano Y, Takai D, Ohishi N, Shinozaki-Ushiku A, Fukayama M, Akahane M, Nakajima J, Nagase T.
Successful Treatment of Mediastinal Unicentric Castleman's Disease Using Video-Assisted Thoracoscopic Surgery with Preoperative Embolization.
Case Rep Med. 2013;2013:354507.
PMID: 24198836

Kawakami M, Ishikawa R, Amano Y, Sunohara M, Watanabe K, Ohishi N, Yatomi Y, Nakajima J, Fukayama M, Nagase T, Takai D.
Detection of novel paraja ring finger 2-fer tyrosine kinase mRNA chimeras is associated with poor postoperative prognosis in non-small cell lung cancer.
Cancer Sci. 2013 Nov;104(11):1447-54
PMID: 23931849

Kawakami M, Morita S, Sunohara M, Amano Y, Ishikawa R, Watanabe K, Hamano E, Ohishi N, Nakajima J, Yatomi Y, Nagase T, Fukayama M, Takai D.
FER overexpression is associated with poor postoperative prognosis and cancer-cell survival in non-small cell lung cancer.
Int J Clin Exp Pathol. 2013;6(4):598-612
PMID: 23573306

Isshiki T, Yamaguchi T, Yamada Y, Maemura K, Makita K, Takeshima H, Hirasawa Y, Yamaguchi Y, Hosoki K, Suzuki M, Kono C,
Terada J, Tatsumi K.
Usefulness of low-dose methotrexate monotherapy for treating sarcoidosis.
Intern Med. 2013;52(24):2727-32.
PMID: 24334575

Kage H, Borok Z.
EMT and interstitial lung disease: a mysterious relationship.
Curr Opin Pulm Med. 2012 Sep;18(5):517-23.
PMID: 22854509

Kitano K, Watanabe K, Emoto N, Kage H, Hamano E, Nagase T, Sano A, Murakawa T, Nakajima J, Goto A, Fukayama M, Yatomi Y, Ohishi N, Takai D.
CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer.
Cancer Sci. 2011 Dec;102(12):2126-31
PMID: 21917081

Kitagawa H, Watanabe K, Kage H, Inoh S, Goto A, Fukayama M, Nagase T, Ohishi N, Takai D.
Pulmonary venous invasion, determined by chest computed tomographic scan, as a potential early indicator of zygomycosis infection: a case series.
J Thorac Imaging. 2012 Jul;27(4):W97-9
PMID: 21912300

Watanabe K, Emoto N, Hamano E, Sunohara M, Kawakami M, Kage H, Kitano K, Nakajima J, Goto A, Fukayama M, Nagase T,
Yatomi Y, Ohishi N, Takai D.
Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer.
Int J Cancer. 2012 Jun1;130(11):2580-90
PMID: 21702040

Yamaguchi Y, Hibi S, Ishii M, Hanaoka Y, Kage H, Yamamoto H, Yamauchi Y, Eto M, Nagase T, Ouchi Y.
Pulmonary features associated with being underweight in older men.
J Am Geriatr Soc. 2011 Aug;59(8):1558-60.
PMID: 21848827

Sunohara M, Kawakami M, Kage H, Watanabe K, Emoto N, Nagase T, Ohishi N, Takai D.
Polymerase reaction without primers throughout for the reconstruction of full-length cDNA from products of rapid amplification of cDNA ends (RACE).
Biotechnol Lett. 2011 Jul;33(7):1301-7
PMID: 21384194

Kage H, Sugimoto K, Sano A, Kitagawa H, Nagase T, Ohishi N, Takai D.
Suppression of transforming growth factor β1 in lung alveolar epithelium-derived cells using adeno-associated virus type 2/5 vectors to carry short hairpin RNA.
Exp Lung Res. 2011 Apr;37(3):175-85.
PMID: 21269064

Watanabe K, Emoto N, Sunohara M, Kawakami M, Kage H, Nagase T, Ohishi N, Takai D.
Treatment of PCR products with exonuclease I and heat-labile alkaline phosphatase improves the visibility of combined bisulfite restriction analysis.
Biochem Biophys Res Commun. 2010 Aug 27;399(3):422-4
PMID: 20674551

Kusakabe M, Watanabe K, Emoto N, Aki N, Kage H, Nagase T, Nakajima J, Yatomi Y, Ohishi N, Takai D.
Impact of DNA demethylation of the G0S2 gene on the transcription of G0S2 in squamous lung cancer cell lines with or without nuclear receptor agonists.
Biochem Biophys Res Commun. 2009 Dec 25;390(4):1283-7
PMID: 19878646

Sunohara M, Hara K, Osamura K, Tashiro N, Shibuya H, Nakahara K, Kishida Y, Tamura K, Hisada T.
Mucosa associated lymphoid tissue (MALT) lymphoma of the thymus with trisomy 18.
Intern Med. 2009;48(23):2025-32.
PMID: 19952486

Kusakabe M, Kutomi T, Watanabe K, Emoto N, Aki N, Kage H, Hamano E, Kitagawa H, Nagase T, Sano A, Yoshida Y, Fukami T, Murakawa T, Nakajima J, Takamoto S, Ota S, Fukayama M, Yatomi Y, Ohishi N, Takai D.
Identification of G0S2 as a gene frequently methylated in squamous lung cancer by combination of in silico and experimental approaches.
Int J Cancer. 2010 Apr 15;126(8):1895-1902
PMID: 19816938

Kage H, Kohyama T, Kitagawa H, Takai D, Kanda Y, Ohishi N, Nagase T.
Non-infectious bronchiolitis as an early pulmonary complication of hematopoietic stem cell transplantation.
Intern Med. 2008;47(1):61-4.
PMID: 18176008

Sano A, Kage H, Sugimoto K, Kitagawa H, Aki N, Goto A, Fukayama M, Nakajima J, Takamoto S, Nagase T, Yatomi Y, Ohishi N,
Takai D.
A second-generation profiling system for quantitative methylation analysis of multiple gene promoters: application to lung cancer.
Oncogene. 2007 Oct 4;26(45):6518-25.
PMID: 17452971

Sugimoto K, Kage H, Aki N, Sano A, Kitagawa H, Nagase T, Yatomi Y, Ohishi N, Takai D.
The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus.
Biochem Biophys Res Commun. 2007 Aug 3;359(3):497-502.
PMID: 17544373



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